TARGET

Transforming AAV by Revolutionary Glue and Evolution Technology

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Evolution

to Gene Therapy​

GluGene Therapeutics is pioneering the development of state-of-the-art AAV vectors
with superiority to conventional vectors through combining two emerging technologies:
i) directed evolution that can design customized AAV vectors with key features as therapeutic carriers,
such as “organ/cell-specific delivery”, “resistance to pre-existing antibody”, and “high packaging efficiency” and
ii) machine learning that can predict capsid-crossovers having novel functions
and expand the scopes of AAV-mediated gene therapy applications.

Linkage

to Gene Therapy​

Inspired by the chemical principle of adhesives molecules, GluGene Therapeutics produces assembled, supramolecular AAV complexes to address the limitations of existing AAV technology.

Beyond Limits with TARGET

Enhancement of organ specificity

Engineering organ/tissue-specific AAV vectors through combining directed evolution and machine learning is a crucial commitment to exploring AAV-mediated genetic medicines capable of inducing highly therapeutic efficacy even at a low dose.

EVASION OF NEUTRALIZING ANTIBODY​

Escaping from neutralizing antibody bindings to AAV surfaces is an important issue to increase therapeutic efficacy and to allow multiple injections. GluGene’s AAV capsid evolutions and surface functionalizations by adhesive molecules address this critical issue.

Expansion of therapeutic payloads

Fabrication of supramolecular assembly of AAVs by adhesive molecules unlimitedly expands the payload of transgene sizes as well as numbers.